A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts.
نویسندگان
چکیده
Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. Identification of the inhibitors was studied by thin layer chromatography, high pressure liquid chromatography and mass spectroscopy.
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ورودعنوان ژورنال:
- FEMS microbiology letters
دوره 132 1-2 شماره
صفحات -
تاریخ انتشار 1995